Abstract #1073

Preliminary Analysis of Longitudinal Functional MRI Data in Diabetic Nephropathy and Healthy Controls

Lu-Ping Li^1,2, Jon Thacker³, Wei Li^1,2, Huan Tan¹, Chi Wang⁴, Orly Kohn⁵, Stuart Sprague^1,2, and Pottumarthi Prasad^1,2

¹Northshore University HealthSystem, Evanston, IL, United States, ²Pritzker School of Medicine, University of Chicago, Chicago, IL, United States, ³Biomedical Engineering, Northwestern Univerisity, Evanston, IL, United States, ⁴Research Institute, Northshore University HealthSystem, Evanston, IL, United States, ⁵University of Chicago, Chicago, IL, United States

BOLD, Diffusion and ASL MRI data were acquired in diabetic nephropathy (DN) patients with stage-3 chronic kidney disease and healthy subjects. Consistent with the chronic hypoxia model for progression of DN, kidneys in subjects with DN had significantly lower blood flow and medullary R2* compared to controls. Intra-subject coefficient of variation (CV) for R2* and ADC was less than 10% in the control group when comparing baseline and 18 month data, suggests R2* and ADC measurements were reproducible over 18 month. CV was higher for blood flow.

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