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Abstract #1227

Probing bone marrow adipocyte cell size in vivo at a clinical 3 T scanner using high b-value DW-MRS at long diffusion times

Dominik J. Weidlich1, Andreas Hock2, Stefan Ruschke1, Daniela Franz1, Katja Steiger3, Thomas Skurk4, Hans Hauner4, Ernst J. Rummeny1, and Dimitrios C. Karampinos1

1Department of Diagnostic and Interventional Radiology, Technical University Munich, Munich, Germany, 2Philips Healthcare, Hamburg, Germany, 3Department of Pathology, Technical University Munich, Munich, Germany, 4Else Kröner Fresenius Center for Nutritional Medicine, Technical University Munich, Munich, Germany

Despite its strong relevance in metabolism, non-invasive measurement of adipocyte size remains an unmet need. High b-value DW-MRS has been previously applied to probe diffusion restriction effects of intramyocellular lipids or brown adipocytes using preclinical systems with strong gradient systems. The present work proposes a methodology to in vivo probe diffusion restriction effects in bone marrow adipocytes with high b-value long diffusion time DW MRS in a clinical system and examines the feasibility of bone marrow adipocyte size estimation in the tibia of healthy subjects.

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