Abstract #1891

Validation of quantitative pre-clinical pseudo-continuous ASL in rat brain

Manon A. Simard¹, James R. Larkin¹, Alexandre A. Khrapitchev¹, James A. Meakin², Thomas W. Okell², Peter Jezzard², Michael A. Chappell³, and Nicola R. Sibson¹

¹CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, ²FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ³Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, United Kingdom

Guidelines for pre-clinical ASL are lacking. We propose MRI parameters for the use of pseudo-continuous ASL in rats. Carotid artery velocity was determined in three rat strains. Bloch simulations for ASL with this information and with parameters for pre-clinical scanners were used to determine the optimal width of the tagging plane required for blood inversion in this smaller species. The use of multiple post-label delays (PLD) in ASL-MRI generated blood arrival maps indicating that a PLD of 550ms was sufficient. Validation of CBF maps generated from ASL was performed using autoradiography, the current gold-standard technique for pre-clinical perfusion measurement.

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