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Abstract #1893

Multiphase pseudo-continuous ASL to image cerebral blood flow in mice at 9.4T

Jessica Buck1, James Larkin1, Alexandr Khrapichev1, Manon Simard1, Kevin Ray1, Michael Chappell2, and Nicola Sibson1

1Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom

Pseudo-continuous arterial spin labelling is regarded as the gold standard for clinical ASL, and can be improved in humans using multiphase sequences, but has not previously been implemented in mice. A multiphase pseudo-continuous ASL sequence to measure cerebral blood flow in mice was successfully implemented using respiratory triggering and optimisation of imaging readout, tag placement, labelling bolus duration, and post-label delay. Multiphase pseudo-continuous ASL is sensitive to changes in perfusion in an intracerebral glioma model.

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