Abstract #1916

Parameters From Dynamic Contrast-Enhanced Magnetic Resonance Imaging Are Biomarkers Predicting Response after Radiation to Brain Metastases

Zhuo Shi¹, Lizhi Xie², Peng Wang¹, Xinming Zhao¹, and Han Ouyang¹

¹National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China, ²GE HealthCare, MR Research China, Beijing, People's Republic of China

Dynamic contrast-enhanced (DCE) MRI provides additional information regarding blood-brain barrier integrity, and K^trans is directly proportional to the level of permeability of the blood-brain barrier. In our study, we found demonstrates that SRS of cerebral metastasis is associated with a reduction of K^trans values in the early post-treatment period. DCE-MRI derived parameters of K^trans may be a promising imaging biomarker of tumor aggressiveness.

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