Abstract #1934

Making Myelin Water Imaging Mainstream: Multi-site and Multi-vendor Reproducibility

Emil Ljungberg¹, Julien Cohen-Adad², Lisa Eunyoung Lee¹, Alexander Rauscher³, David Li^1,4, Anthony Traboulsee¹, Alex MacKay^4,5, Chase Figley⁶, Jongho Lee⁷, and Shannon Kolind^1,4

¹Medicine, Neurology, University of British Columbia, Vancouver, BC, Canada, ²Electrical Engineering, Polytechnique Montréal, Montreal, QC, Canada, ³Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁶Radiology, University of Manitoba, Winnipeg, MB, Canada, ⁷Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Myelin water imaging (MWI) is a quantitative T₂ relaxation-based MRI technique, measuring the amount of myelin in the central nervous system. We investigated the reproducibility of MWI using GRASE with 3T MR scanners from two different vendors at two sites. Using stimulated echo correction, differences in the refocusing flip angle profile between the two sites were effectively corrected for and myelin estimates between the two sites were found to be highly correlated (slope=1.12, R²=0.96). This is the first multi-vendor and multi-site reproducibility study of MWI using GRASE, encouraging future multicenter MWI studies.

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