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Abstract #2115

Comparison of methods for high spatial-resolution breast diffusion imaging

Jessica Ann McKay1, Sudhir Ramanna2, Steen Moeller2, Edward J Auerbach2, Gregory J Metzger2, Michael T Nelson2, Kamil Ugurbil2, Essa Yacoub2, and Patrick J Bolan2

1Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, 2Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Diffusion weighted imaging (DWI) has applications in the screening, diagnosis, and treatment monitoring of breast cancer, but its clinical value in is limited by the low resolution and artifacts of standard methods. In this work we compared a standard method with two high-resolution techniques: read-out segmented EPI (RS-EPI) and single-shot simultaneous multi-slice EPI with in-plane slice encoding (SMS-IPSE). Both the SMS-IPSE and RS-EPI methods can produce high-resolution, accurate diffusion-weighted images at the cost of decreased SNR within a clinically practical 5-minute time window, enabling the detection of smaller lesions.

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