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Abstract #2123

Ductal carcinoma in situ of the breast: Investigation of quantitative MRI features of lesion and normal tissue to predict recurrence after treatment

Averi Kitsch1,2, Brian Johnston1,2, Savannah Partridge1,2, and Habib Rahbar1,2

1Radiology, University of Washington, Seattle, WA, United States, 2Breast Imaging, Seattle Cancer Care Alliance, Seattle, WA, United States

Ductal carcinoma in situ (DCIS) is a pre-invasive breast cancer that may be overtreated due to lack of reliable clinical and pathological prognostic features. Kinetics parameters on dynamic contrast-enhanced MRI have shown promise as breast cancer risk biomarkers. We compared imaging parameters of lesions and normal breast tissue between patients with DCIS recurrence and matched controls and found that patients with larger lesions with higher signal enhancement ratio (SER) and higher background parenchymal enhancement (BPE) on preoperative MRI were more likely to recur. These MRI biomarkers show promise for decreasing DCIS overtreatment and warrant further study in larger cohorts.

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