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Abstract #2156

Point-resolved spectroscopy with self-navigation for precise reversible transverse relaxation quantification in pulmonary tissue robust to breathing state variation at 1.5 and 3 Tesla

Jascha Zapp1, Sebastian Domsch1, Sebastian Weingärtner1,2,3, and Lothar R Schad1

1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, 2Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

The reversible transverse relaxation time is currently under investigation as a promising biomarker for diagnosis of lung diseases. We propose an enhanced point-resolved spectroscopy sequence for precise relaxation quantification with self-navigation robust to breathing state variation. The obtained relaxation times show evidence for sensitivity to tissue structure alteration during normal breathing. This approach potentially enables a precise assessment of tissue structure in pulmonary diseases such as fibrosis and COPD.

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