Abstract #2156

Point-resolved spectroscopy with self-navigation for precise reversible transverse relaxation quantification in pulmonary tissue robust to breathing state variation at 1.5 and 3 Tesla

Jascha Zapp¹, Sebastian Domsch¹, Sebastian Weingärtner^1,2,3, and Lothar R Schad¹

¹Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, ²Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, ³Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

The reversible transverse relaxation time is currently under investigation as a promising biomarker for diagnosis of lung diseases. We propose an enhanced point-resolved spectroscopy sequence for precise relaxation quantification with self-navigation robust to breathing state variation. The obtained relaxation times show evidence for sensitivity to tissue structure alteration during normal breathing. This approach potentially enables a precise assessment of tissue structure in pulmonary diseases such as fibrosis and COPD.

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