We implemented a spiral k-space sampling approach for Dynamic hyperpolarized 129Xe Ventilation Imaging (DXeVI) of human lungs. The gas-inflow effect, susceptibility artifacts, spatial and temporal resolutions for capturing Gas Flow Patterns (GFPs) were quantified in the gas-flow phantom and compared to corresponding simulated GFPs. DXeVI of GFPs are shown to be sensitive to small gas flow changes between the anterior and posterior lung regions in healthy three subject. This technique can potentially be used to detect and quantify ventilation defects associated with early stage COPD or asthma to assess disease severity, response to treatments and to identify disease progression.
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