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Abstract #2221

Differentiation of Brain Infections from Necrotic Glioblastomas using Diffusion Tensor Imaging and Perfusion Weighted Imaging

Sumei Wang1, SANJEEV CHAWLA1, Mohamed Metkees1,2, Seyed Ali Nabavizadeh1, Gaurav Verma1, Arastoo Vossough1, Suyash Mohan1, and Harish Poptani1,3

1Radiology, UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA, United States, 2Biological Anthropology, National Research Centre, Cairo, Egypt, 3Cellular and Molecular Physiology, University of Liverpool, Liverpool, United Kingdom

To determine whether combined use of diffusion and perfusion MRI can help in differentiating brain infections from glioblastomas (GBMs), 13 patients with infections and 20 patients with GBMs underwent DTI and DSC-PWI. Significantly lower median values of mean diffusivity (MD) and higher fractional anisotropy (FA) were observed in central core of infective lesions than in GBMs. Additionally, significantly decreased median and maximum values of relative cerebral blood volume (rCBV) from enhancing region were observed in patients with infections compared with those of GBMs. The best classification model consisted of MD from central core and rCBVmax from enhancing region.

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