Abstract #2268

Ultra-high spatial resolution imaging in vivo of human retina at 3T

Yongsheng Chen^1,2, Yang Song³, Jiani Hu², Yongquan Ye², Yu Wang³, Ying Wang⁴, Bruce A. Berkowitz^5,6, Yan kang¹, Guang Yang³, and E. Mark Haacke^1,2,3,4,7

¹Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, People's Republic of China, ²Department of Radiology, Wayne State University, Detroit, MI, United States, ³Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, People's Republic of China, ⁴Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, ⁵Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI, United States, ⁶Department of Ophthalmology, Wayne State University, Detroit, MI, United States, ⁷The MRI Institute for Biomedical Research, Detroit, United States

Imaging in vivo human retina remains a considerable challenge due to the thinness of the retina and eye motion. Here we provide proof-of-concept data supporting the use of an asymmetric gradient echo scan with TE to 5 ms and an effective resolution of 37 μm in the readout direction after partial Fourier reconstruction. To reduce motion, we employed a cued-blinking strategy and collected the data multiple times and averaged data that after co-registration. Preliminary results showed retina/choroid layer clearly with sufficient SNR to obtain a transretinal T1 map from vitreous body to sclera.

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