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Abstract #2269

Age-related MRI changes in the connective tissues of the eye

Yolandi van der Merwe1,2, John S. Gnalian3, Ning-Jiun Jan1,2, Ian A. Sigal1,2, and Kevin C. Chan1,2,3

1Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 3Neuroimaging Laboratory, University of Pittsburgh, Pittsburgh, PA, United States

The structural organization and compositions of the corneoscleral shell determine the biomechanical behavior of the eye, and are important in aging and diseases such as glaucoma and myopia. However, characterizing the structure and composition of the eye and their changes with age or intraocular pressure remains a challenge. In this study, we showed that T2 mapping, magnetization transfer MRI and diffusion tensor MRI can be used to detect and differentiate age- and intraocular pressure-related changes in the porcine eyes. Multi-modal MRI may be useful for evaluating the biomechanical and (patho-)physiological mechanisms in the corneoscleral shell non-invasively and quantitatively.

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