Abstract #2573

Spatial Patterns of Intersubject CBF Variability in the CARDIA study

Yunwen Shao¹, Zhengjun Li², Marta Vidorreta², Sudipto Dolui³, Nick Bryan³, and John Detre⁴

¹Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China, ²Department of Neurology, School of Medicine, University of Pennsylvania, ³Department of Radiology, School of Medicine, University of Pennsylvania, ⁴Departments of Neurology and Radiology, School of Medicine, University of Pennsylvania

Variability in regional relative cerebral blood flow (CBF) from resting-state arterial spin labeling (ASL) MRI data obtained in a large (N=436) cohort were examined using spatial Independent Components Analysis (ICA). Some spatial patterns of intersubject CBF variability resembled known resting-state functional networks, and were largely reproducible across split samples. Network relative CBF fluctuation across subjects was about 14%.

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