Identification and differentiation of intracranial vessel wall pathologies requires multi-contrast high isotropic resolution 3D vessel wall MRI. However scan times for multi-contrast intracranial vessel wall imaging (IVWI) are too long to be tolerated by patients. We have developed a tailored k-space undersampling and partially parallel reconstruction strategy to accelerate 0.5mm 3D isotropic multi-contrast IVWI sequences to five minutes each. We demonstrate an accelerated multi-contrast IVWI protocol that provides similar vessel delineation as fully sampled sequences. Protocol performance was assessed in patients with intracranial atherosclerotic disease and showed clear delineation of vessel wall and atherosclerotic plaque.
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