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Abstract #2932

Mapping the exchange kinetics of high-energy phosphates in the human calf muscle by direct 31P MRSI at 7T

Andreas Korzowski1, Sarah Neumann1, Ludwig Dominik1, Loreen Ruhm1, Mark E. Ladd1, and Peter Bachert1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

31P MRS allows the non-invasive observation of high-energy phosphate turnover in vivo. A model incorporating the effects of exchange processes onto the transverse steady-state magnetization was derived, which allows the direct estimation of relaxation rates from signal intensities in MRSI datasets. Multiple 31P MRSI datasets with different excitation parameters of four healthy were evaluated. Spatially-resolved turnover rates of high-energy phosphates could be estimated and are in agreement with literature values proving feasibility of the proposed approach.

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