Meeting Banner
Abstract #2934

Phosphocreatine T1 in human gastrocnemius muscle at 7T increases during exercise, measured by localized 31P MRS with progressive saturation

Martin Meyerspeer1, Albrecht Ingo Schmid1, Fabian Niess1, Georg Bernd Fiedler1, Sigrun Goluch1, Michale Wolzt2, and Ewald Moser1

1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 2Department of Internal Medicine III, Medical University of Vienna, Austria

Alterations in T1 have implications on the physiological interpretation of dynamic high-energy phosphate data. Progressive saturation during rest-exercise-recovery experiments was used to simultaneously quantify PCr depletion, recovery and T1 values. The data were acquired using localised 31P MRS in human gastrocnemius. Apparent T1 values increased from 5.0 ± 0.4 s at rest to an average value of 5.8 ± 0.5 s during exercise, with a peak in early exercise and returning towards baseline values before exercise was ceased. These alterations may be explained by changes in the chemical exchange rates of PCr with ATP and Pi.

This abstract and the presentation materials are available to members only; a login is required.

Join Here