Abstract #2978

Attenuated excitatory metabolism in the prefrontal Cortex of single prolonged stress model: in vivo and ex vivo proton magnetic resonance spectroscopy

Song-I LIm^1,2, Kyu-Ho Song¹, Chi-Hyeon Yoo^1,2, Dong-Choel Woo², and Bo-Young Choe¹

¹Department of Biomedical Engineering, and Research Institute of Biomedical Engineering. The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, ²Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of

The purpose of the study was to evaluate neurochemical changes in the prefrontal cortex of rats during time-dependent sensitization in the single prolonged stress (SPS) model that reveals pathogenetic neurometabolites characteristic of posttraumatic stress disorder by using in vivo and ex vivo proton magnetic spectroscopy. After the time-sensitization period, Glu and Cr levels were reduced and Cho and Lac levels were increased in SPS group in comparison with control group. These indicate that SPS induced sustained adaptation of the glutamatergic activity in PFC.

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