1H-MRS technology combined with Lcmodel software were used to quantitative the concentration of metabolites of posterior cingulate gyrus (PCC) in Parkinson’s disease patients with(PDCI) and without cognitive impairment(PDN), and MMSE and MOCA tests were also performed. Compared with controls, the concentration of total creatine (tCr), N-acetylaspartate(NAA), myo-Inositol(mI), Glutathione (GSH), as well as glycerophosphocholine + phosphocholine (tCho) were found significantly decreased in PCC in PDCI group , but no changes were found in PDN. Additionally, correlations between concentration of tCr, GSH, tCho, NAA and MMSE (MoCA) scores can also be found . These results may indicate that the metabolites abnormalities in PCC might be used as a biomarker to track cognitive decline in Parkinson's disease in a clinical setting.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords