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Abstract #3091

Probing metabolic alterations in lung injury during protective and non-protective ventilation using hyperpolarized [1-13C] pyruvate

Mehrdad Pourfathi1, Yi Xin1, Maurizio Cereda2, Stephen Kadlecek1, Harrilla Profka1, Hooman Hamedani1, Ian Duncan1, Sarmad Siddiqui1, Nicholas Drachman1, Kai Ruppert1, and Rahim Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

In this study, hyperpolarized [1-13C]-pyruvate imaging was used to investigate the effect of positive-end expiratory pressure (PEEP) on the stabilization of lung metabolism after injury. Results demonstrated significantly lower lactate-to-pyruvate ratio in rats ventilated with PEEP.

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