Abstract #3091

Probing metabolic alterations in lung injury during protective and non-protective ventilation using hyperpolarized [1-13C] pyruvate

Mehrdad Pourfathi¹, Yi Xin¹, Maurizio Cereda², Stephen Kadlecek¹, Harrilla Profka¹, Hooman Hamedani¹, Ian Duncan¹, Sarmad Siddiqui¹, Nicholas Drachman¹, Kai Ruppert¹, and Rahim Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

In this study, hyperpolarized [1-¹³C]-pyruvate imaging was used to investigate the effect of positive-end expiratory pressure (PEEP) on the stabilization of lung metabolism after injury. Results demonstrated significantly lower lactate-to-pyruvate ratio in rats ventilated with PEEP.

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