Abstract #3279

4D Ferumoxytol Enhanced MUSIC: Value-Based MRI in Neonates and Infants with Congenital Heart Disease

Kim-Lien Nguyen^1,2, Fei Han^1,3, Ziwu Zhou^1,3, Daniel Z Brunengraber^1,3, Ihab Ayad⁴, Daniel S Levi⁵, Gary M Satou⁵, Brian L Reemtsen⁶, Peng Hu^1,3, and J. Paul Finn^1,3

¹Diagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, ³Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁴Department of Anesthesiology, David Geffen School of Medicine at UCLA, ⁵Division of Pediatric Cardiology, David Geffen School of Medicine at UCLA, ⁶Department of Cardiothoracic Surgery, David Geffen School of Medicine at UCLA

Conventional cardiovascular magnetic resonance imaging (MRI) in congenital heart disease (CHD) enables dynamic morphologic and vascular assessment. However, current techniques require multi-slice cine imaging and angiography with supplemental phase-contrast. We demonstrate that 4D multiphase steady state imaging with contrast (MUSIC) can provide high-resolution dynamic images of all relevant cardiovascular anatomy without breath-holding or operator input in a cohort of neonates and infants with CHD. Further, 4D MUSIC has high clinical impact on the care of small children.

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