Abstract #3412

Multiparametric MRI-Defined Prostate Cancer Includes Heterogeneous Pathologies

Qingsong Yang¹, Ze-Zhong Ye², Joshua Lin³, Peng Sun⁴, Chunyu Song⁵, Yasheng Zhu⁶, Jianping Lu¹, and Sheng-Kwei Song⁵

¹Department of Radiology, Changhai Hospital, Shanghai, China, shanghai, People's Republic of China, ²Chemistry, Department of Chemistry, Washington University, St. Louis, MO, United States, ³Department of Biology, Washington University, St. Louis, MO, United States, ⁴Department of Radiology, Washington University, St. Louis, MO, United States, ⁵Department of Biomedical Engineering, Washington University, St. Louis, MO, United States, ⁶Department of Urology, Changhai Hospital, Shanghai, China

Due to the overlapping apparent diffusion coefficient of prostate cancer (PCa), inflammation, and benign prostatic hyperplasia (BPH), mpMRI commonly results in false-positive PCa diagnosis. Based on the histology of whole mount section from prostatectomy, heterogeneous pathologies was clearly seen in the mpMRI-defined cancer region. Our recently-developed diffusion MRI histology (D-Histo) approach successfully differentiated and quantified PCa, inflammation and BPH. We report mpMRI and D-Histo results on 178 PCa-suspicious patients to demonstrate the causes of mpMRI false-positive PCa diagnosis.

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