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Abstract #3412

Multiparametric MRI-Defined Prostate Cancer Includes Heterogeneous Pathologies

Qingsong Yang1, Ze-Zhong Ye2, Joshua Lin3, Peng Sun4, Chunyu Song5, Yasheng Zhu6, Jianping Lu1, and Sheng-Kwei Song5

1Department of Radiology, Changhai Hospital, Shanghai, China, shanghai, People's Republic of China, 2Chemistry, Department of Chemistry, Washington University, St. Louis, MO, United States, 3Department of Biology, Washington University, St. Louis, MO, United States, 4Department of Radiology, Washington University, St. Louis, MO, United States, 5Department of Biomedical Engineering, Washington University, St. Louis, MO, United States, 6Department of Urology, Changhai Hospital, Shanghai, China

Due to the overlapping apparent diffusion coefficient of prostate cancer (PCa), inflammation, and benign prostatic hyperplasia (BPH), mpMRI commonly results in false-positive PCa diagnosis. Based on the histology of whole mount section from prostatectomy, heterogeneous pathologies was clearly seen in the mpMRI-defined cancer region. Our recently-developed diffusion MRI histology (D-Histo) approach successfully differentiated and quantified PCa, inflammation and BPH. We report mpMRI and D-Histo results on 178 PCa-suspicious patients to demonstrate the causes of mpMRI false-positive PCa diagnosis.

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