We performed multi-b value and multi-TE diffusion imaging with two repetition on healthy human prostate to evaluate the influence of TE on reproducibility and quantification of IVIM diffusion model. The result showed that the Dstar and f parameters of IVIM model had high CVs and particularly high variability, while conventional ADC and D showed high reproducibility and a moderate TE-dependency in the peripheral zone and mild TE-dependency in the central zone. This work suggests that using diffusion parameters as quantitative biomarkers should consider the reproducibility and TE-dependency in clinical studies.
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