Abstract #3451

Quantitation of DTI changes associated with muscle injury using a 3D printed phantom

David B Berry¹, Shangting You², John Warner², Lawrence Frank³, Shaochen Chen², and Samuel R Ward^1,3,4

¹Bioengineering, University of California, San Diego, San Diego, CA, United States, ²Nanoengineering, University of California, San Diego, San Diego, CA, United States, ³Radiology, University of California, San Diego, San Diego, CA, United States, ⁴Orthopaedic Surgery, University of California, San Diego, San Diego, CA, United States

Diffusion tensor imaging has been proposed as a tool to non-invasively assess skeletal muscle microstructure, which would be of significant clinical value. However, its application to the assessment of changes in muscle microstructure associated with injury, pathology, or age remain poorly defined because it is difficult to precisely control muscle microstructural features in vivo. Recent advances in bottom up fabrication technologies allow precision-engineered diffusion phantoms with histology informed skeletal muscle geometry to be manufactured. Therefore, the goal of this study was to develop skeletal muscle phantoms at relevant size scales in order to relate microstructural features to MRI-based diffusion measurements.

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