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Abstract #3593

Chicken Embryo: An Excellent Platform for Monitoring Zika Virus Induced Microcephaly and Tracking Stem Cells

Qun Zhao1, Forrest Goodfellow2, Gregory Simchick1, Thomas Hodge3, Melinda Brindley3, and Steven Stice2

1Bioimaging research Center, University of Georgia, Athens, GA, United States, 2Regenerative Bioscience Center, University of Georgia, Athens, GA, United States, 3Department of Infectious Diseases, University of Georgia, Athens, GA, United States

A chicken embryo is the developmental biology’s oldest model organism. In ovo development of the chicken embryo closely mirrors human embryo development. The relatively large size, ease of access, and lack of maternal motion generated in pregnant mammals are distinct advantages the chicken embryo model provides. The chicken embryo provides an excellent platform for monitoring morphology and metabolism of central neural system (CNS) by using MRI or NMR spectroscopy over the course of development. In this presentation our recent work on monitoring Zika virus induced microcephaly and tracking stem cells are presented.

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