The
lack of dietary essential amino acid leucine influences energy metabolism via
hypothalamic leptin signaling pathway. However, these neural circuits and its
relationship with pathogenesis of obesity still remain unclear. In this work we
investigated the hypothalamic neural pathway, abdominal fat and liver fat by
multi-parametric imaging in leucine deficient diet fed mice. MEMRI results
indicated that leu deficiency triggers neuronal inhibition in certain
hypothalamic regions suggesting POMC neuronal pathway involvement in enhanced
energy expenditure through leptin signaling pathway. Combined with systemic
metabolic changes this may facilitate in understanding of amino acid sensing
and metabolic regulatory network of energy homeostasis.
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