Abstract #3595

Detecting neuronal activity in rat model of dementia with Lewy bodies by using MEMRI

Meng-Syuan Lin¹, Ying-Jui Ho², and Jun-Cheng Weng^1,3

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, ³Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Dementia with Lewy bodies (DLB) is thought to be the second commonest cause of neurodegenerative dementia in older people, accounting 15 to 25% cases at autopsy. However, to date there are no reliable methods of instrumental and laboratory diagnosis of this disease while its treatment is based on reducing the symptoms. The drug X has been shown to have neuroprotective effects in neurodegenerative diseases. Therefore, we aimed to clarify the medicinal effectiveness of drug X through manganese-enhanced magnetic resonance imaging (MEMRI). Our results indicated that drug X may have clinical potential in the treatment of DLB.

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