Meeting Banner
Abstract #3596

Aortic endothelial injury modifies plaque composition at a distally located site through increased monocyte extravasation

Begona Lavin Plaza1, Alkystis Phinikaridou1, Marcelo Andia Kohnenkampf2, and Rene Botnar1

1Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Radiology Department, Universidad Catolica de Chile, Santiago de Chile, Chile

The deleterious impact of atherosclerosis on other cardiovascular diseases has recently been shown, but the effect of vascular alterations on plaque formation at a distal site, including the underlying mechanisms of this systemic response, has not been elucidated. In this study, we used an albumin-binding contrast agent to assess whether (1) endothelial injury in the abdominal aorta accelerates plaque progression in the brachiocephalic artery located distally to the site of injury and (2) whether monocytes can be the link between acute and systemic response.

This abstract and the presentation materials are available to members only; a login is required.

Join Here