Abstract #3597

Precise longitudinal MRI tracking of systemically infused dual labelled mesenchymal stem cells and their regenerative potential in traumatic brain injury mice

Sushanta Kumar Mishra^1,2, Subash Khushu¹, and Gurudutta Gangenahalli²

¹NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India, Delhi, India, ²Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Stem cells transplantation has emerged as a promising alternative therapeutic due to its potency at injury site. Thus, tracking of stem cells is very essential. Here, we have described a serial in vivo tracking of implanted stem cells through 7T MRI and its differentiation potential into neuronal precursors. T2*-weighted images and relaxation study demonstrated a significant signal loss and effective decrease in T2* relaxation time on day-3 at injury site. Expression of neuronal markers like GFAP, MAP2 and NeuN were observed in transplanted MSCs. The proposed procedure could be extrapolated for stem cell tracking and therapies in various neurodegenerative diseases.

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