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Abstract #3598

Molecular Imaging of the effects of monocyte chemoattractant protein-1 (MCP-1) on extracellular matrix remodeling following myocardial infarction

Isabel Teixeira Ramos1,2, Markus Henningsson1, Maryam Nezafat1, Begoña Lavin1, Silvia Lorrio1, Alkystis Phinikaridou1,2, Ulrich Flögel3, Ajay Shah2,4, and René Botnar1,2

1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Cardiovascular Division, The British Heart Foundation Centre of Excellence, King's College London, London, United Kingdom, 3Heinrich Heine University Düsseldorf, Düsseldorf, Germany, 4Cardiovascular Division, James Black Centre, King's College London, London, United Kingdom

After a myocardial infarction (MI) the degree of inflammation and its timely resolution, together with the degradation and deposition of extracellular matrix proteins are key processes in post-MI healing. Monocyte chemoattractant protein-1 (MCP1) plays an important role in the recruitment of monocytes/macrophages and its absence has revealed a significant reduction of inflammatory cell recruitment and subsequent ECM protein production in the infarcted area. Here, we explored the merits of multinuclear 1H/19F MRI for the simultaneous assessment of myocardial inflammation and remodelling in a murine model of MI. 19F containing nanoparticle that is avidly taken up by macrophages was used to investigate inflammatory cell recruitment into injured myocardium2, and a small molecular weight gadolinium-based elastin-specific MR contrast agent was used to evaluate changes of elastin content post-MI3.

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