After a myocardial infarction (MI) the degree of inflammation and its timely resolution, together with the degradation and deposition of extracellular matrix proteins are key processes in post-MI healing. Monocyte chemoattractant protein-1 (MCP1) plays an important role in the recruitment of monocytes/macrophages and its absence has revealed a significant reduction of inflammatory cell recruitment and subsequent ECM protein production in the infarcted area. Here, we explored the merits of multinuclear 1H/19F MRI for the simultaneous assessment of myocardial inflammation and remodelling in a murine model of MI. 19F containing nanoparticle that is avidly taken up by macrophages was used to investigate inflammatory cell recruitment into injured myocardium2, and a small molecular weight gadolinium-based elastin-specific MR contrast agent was used to evaluate changes of elastin content post-MI3.
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