Abstract #3599

19F-based MRI cell tracking shows that the density of tumour associated macrophages in breast tumours corresponds to tumour aggressiveness and metastatic potential

Ashley V Makela^1,2, Jeffrey M Gaudet^1,2, and Paula J Foster^1,2

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada

Tumour associated macrophages (TAMs) have been associated with tumour aggressiveness, including tumour growth and metastatic potential. ¹⁹F-based MRI is used in this study to track these cells in vivo, revealing the ability to differentiate TAM content between 3 murine models of breast cancer. Highly aggressive tumours had significantly higher ¹⁹F signal when compared to the low and non aggressive variants. This information may be of use as a biomarker, to differentiate between tumours with high infiltration of TAMs, which have the propensity to metastasize and progress quicker, versus tumours with less TAMs, which may not advance as quickly.

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