Abstract #3693

High Spatiotemporal Resolution bSSFP Imaging of Hyperpolarized 13C Lactate and Pyruvate using Spectral Suppression of Alanine and Pyruvate-hydrate at 3T

Eugene Milshteyn^1,2, Cornelius von Morze¹, Jeremy W. Gordon¹, Zihan Zhu^1,2, Peder E. Z. Larson^1,2, and Daniel B. Vigneron^1,2

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²UC Berkeley-UCSF Graduate Program in Bioengineering, UCSF and University of California, Berkeley, San Francisco, CA, United States

The bSSFP sequence provides high spatial and temporal resolution capabilities, but has a difficult to manage frequency response at 3T with regards to hyperpolarized [1-¹³C]pyruvate and its products. The purpose of this project was to integrate a spectral suppression pulse, designed to suppress alanine and pyruvate-hydrate, with the bSSFP sequence to image [1-¹³C]pyruvate and its conversion to [1-¹³C]lactate. The results showed no significant effect on quantitative analysis of lactate-to-pyruvate ratios or k_pl after suppression of alanine and pyruvate-hydrate. Subsequently, dynamic imaging of [1-¹³C]pyruvate and [1-¹³C]lactate at high in-plane spatial resolution was achieved with the bSSFP sequence.

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