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Abstract #3693

High Spatiotemporal Resolution bSSFP Imaging of Hyperpolarized 13C Lactate and Pyruvate using Spectral Suppression of Alanine and Pyruvate-hydrate at 3T

Eugene Milshteyn1,2, Cornelius von Morze1, Jeremy W. Gordon1, Zihan Zhu1,2, Peder E. Z. Larson1,2, and Daniel B. Vigneron1,2

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, UCSF and University of California, Berkeley, San Francisco, CA, United States

The bSSFP sequence provides high spatial and temporal resolution capabilities, but has a difficult to manage frequency response at 3T with regards to hyperpolarized [1-13C]pyruvate and its products. The purpose of this project was to integrate a spectral suppression pulse, designed to suppress alanine and pyruvate-hydrate, with the bSSFP sequence to image [1-13C]pyruvate and its conversion to [1-13C]lactate. The results showed no significant effect on quantitative analysis of lactate-to-pyruvate ratios or kpl after suppression of alanine and pyruvate-hydrate. Subsequently, dynamic imaging of [1-13C]pyruvate and [1-13C]lactate at high in-plane spatial resolution was achieved with the bSSFP sequence.

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