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Abstract #3694

Dynamic Nuclear Polarization across the barrier: a Focused Ultrasound approach

Tom H. Peeters1, Thiele Kobus1, Andor Veltien1, Arend Heerschap1, and Tom W.J. Scheenen1

1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands

The delivery of targeted metabolic compounds can be hindered by a natural barrier in the brain. Nowadays, focused ultrasound techniques allow temporarily opening of this blood-brain barrier (BBB). Here we investigated the feasibility to combine this technique with dynamic imaging of hyperpolarized (HP) pyruvate. After opening the BBB in a focal spot, we acquired in vivo HP pyruvate images of the mouse brain using a dynamic gradient-echo imaging acquisition scheme at 7T. This approach eventually allows investigations with hyperpolarized compounds in the brain that are usually hindered by the BBB or suffer from a too slow uptake for DNP-imaging.

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