The delivery of targeted metabolic compounds can be hindered by a natural barrier in the brain. Nowadays, focused ultrasound techniques allow temporarily opening of this blood-brain barrier (BBB). Here we investigated the feasibility to combine this technique with dynamic imaging of hyperpolarized (HP) pyruvate. After opening the BBB in a focal spot, we acquired in vivo HP pyruvate images of the mouse brain using a dynamic gradient-echo imaging acquisition scheme at 7T. This approach eventually allows investigations with hyperpolarized compounds in the brain that are usually hindered by the BBB or suffer from a too slow uptake for DNP-imaging.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords