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Abstract #3799

Mulitplexed OxFlow for Rapid Estimation of Whole-Brain Oxygen Consumption at Rest and During Apneic Challenge

Hyunyeol Lee1, Michael C. Langham1, Cheng Li1, Ana E. Rodriguez-Soto1, and Felix W. Wehrli1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

The OxFlow method provides a global CMRO2 estimation in a single pulse sequenc by combining phase-contrast-based flow mapping with estimation of venous oxygen saturation via susceptometry-based oximetry. However, four-interleave in convenional OxFlow makes it difficult to measure rapid changes of brain metabolic states such as response to apneic stimuli. Thus, in this work a highly efficient, multiplexed imaging based OxFlow method was developed and its feasibility was demonstrated in estimation of dynamic CMRO2 in response to an apneic challenge.

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