The OxFlow method provides a global CMRO2 estimation in a single pulse sequenc by combining phase-contrast-based flow mapping with estimation of venous oxygen saturation via susceptometry-based oximetry. However, four-interleave in convenional OxFlow makes it difficult to measure rapid changes of brain metabolic states such as response to apneic stimuli. Thus, in this work a highly efficient, multiplexed imaging based OxFlow method was developed and its feasibility was demonstrated in estimation of dynamic CMRO2 in response to an apneic challenge.
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