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Abstract #3800

Quantification of cerebral venous oxygenation using a two-compartment model of local phase evolution

Elena Kleban1, Richard Bowtell1, Penny Gowland1, and Molly Bright1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, UK, Nottingham, United Kingdom

We propose that a two-compartment model of the evolution of signal phase, processed using Frequency Difference Mapping, could be applied to study venous oxygenation and architecture at the microscopic scale. This study demonstrates proof-of-concept, quantifying Yv in large vessels, and tests the sensitivity of these values to hyperoxia. We discuss how this new method can be adapted to probe venous microstructure within grey matter, providing more sensitive measures of brain tissue function.

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