Abstract #3801

A feasibility study of using noninvasive renal oxygenation imaging to delineate different severities of renal ischemia in atheroembolic renal disease model

Chengyan Wang¹, Fei Gao², Hanjing Kong¹, Li Jiang³, Wenjian Huang¹, Rui Wang⁴, Kai Zhao⁴, Yan Jia⁵, Hui Xu⁵, He Wang⁶, Xiaodong Zhang⁴, Li Yang⁵, Jue Zhang^1,2, Xiaoying Wang^1,4, and Jing Fang^1,2

¹Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, People's Republic of China, ²College of Engineering, Peking University, Beijing, People's Republic of China, ³Philips Healthcare, Suzhou, People's Republic of China, ⁴Department of Radiology, Peking University First Hospital, Beijing, People's Republic of China, ⁵Renal Division, Peking University First Hospital, Beijing, People's Republic of China, ⁶Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, People's Republic of China

Since the use of angiographic and endovascular procedures increased rapidly during the past decades, the frequency of atheroembolic renal disease raised recently. This study demonstrates the feasibility of applying an MRI based oxygenation imaging to evaluate renal ischemia in an atheroembolic renal disease model. The average renal oxygen extraction fraction (OEFs) as well as the ratios between embolized kidney and contralateral kidney show significant differences between groups. Renal OEF measurement appears to be able to delineate different severities of renal ischemia by revealing information about the balance between tubular workload and delivery of oxygen.

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