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Abstract #4141

Functional MRS in patients with mild cognitive impairment and Alzheimer’s disease: Three-year longitudinal study

Soo Hyun Cho1, Geon-Ho Jahng2, Jang-Hoon Oh3, Hyug-Gi Kim3, Hak Young Rhee4, Chang Woo Ryu2, Key-Chung Park1, Dal Mo Yang2, Eui Jong Kim5, and Wook Jin2

1Kyung Hee University Hospital, Seoul, Korea, Republic of, 2Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 3Kyung Hee University, 4Kyung Hee University Hospital at Gangdong, 5Radiology, Kyung Hee University Hospital, Seoul, Korea, Republic of

To measure temporal changes of the metabolite level during a memory task, proton functional MRS (fMRS) data with a single-voxel PRESS sequence were acquired at the precuneus and posterior cingulate brain region during a face-name association task using a 3 Tesla MRI scanner for the 28 cognitive normal elderly, 16 amnestic mild cognitive impairment, and 12 Alzheimer’s disease individuals. We measured the fMRS data three times at the eight-month interval. All of the acquired data were analyzed using LCModel software. Glx at the second trial increased significantly compared to that of the first trial in the novel condition.

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