Abstract #4141

Functional MRS in patients with mild cognitive impairment and Alzheimer’s disease: Three-year longitudinal study

Soo Hyun Cho¹, Geon-Ho Jahng², Jang-Hoon Oh³, Hyug-Gi Kim³, Hak Young Rhee⁴, Chang Woo Ryu², Key-Chung Park¹, Dal Mo Yang², Eui Jong Kim⁵, and Wook Jin²

¹Kyung Hee University Hospital, Seoul, Korea, Republic of, ²Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ³Kyung Hee University, ⁴Kyung Hee University Hospital at Gangdong, ⁵Radiology, Kyung Hee University Hospital, Seoul, Korea, Republic of

To measure temporal changes of the metabolite level during a memory task, proton functional MRS (fMRS) data with a single-voxel PRESS sequence were acquired at the precuneus and posterior cingulate brain region during a face-name association task using a 3 Tesla MRI scanner for the 28 cognitive normal elderly, 16 amnestic mild cognitive impairment, and 12 Alzheimer’s disease individuals. We measured the fMRS data three times at the eight-month interval. All of the acquired data were analyzed using LCModel software. Glx at the second trial increased significantly compared to that of the first trial in the novel condition.

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