Abstract #4142

Quantitative susceptibility mapping (QSM) as a biomarker for evaluating white matter alterations in Parkinson’s disease

Xiaojun Guan¹, Peiyu Huang¹, Qiaoling Zeng¹, Chunlei Liu², Min Xuan¹, Quanquan Gu¹, Xiaojun Xu¹, Nian Wang², Nian Wang², Xinfeng Yu¹, Xiao Luo¹, Jingjing Xu¹, Wei Luo³, Yong Zhang⁴, and Minming Zhang¹

¹Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China, ²Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC, United States, ³Neurology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China, ⁴MR Research, GE Healthcare, Shanghai, People's Republic of China

Myelinated white matter showing diamagnetic susceptibility is important for information transfer in the brain. In Parkinson’s disease, the white matter is damaged secondary to nigral degeneration. Quantitative susceptibility mapping is a novel technique for noninvasive assessment of regional white matter ultrastructure, and provides different information to standard diffusion tensor imaging.

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