Abstract #4619

Correlation of microstructure differences in diffusion MRI scans with Fugl-Meyer assessment scores in stroke subjects

Kyler Hodgson¹, Ganesh Adluru², Lorie Richards³, Jennifer Majersik⁴, and Edward DiBella⁵

¹Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, ²Radiology and Imaging Sciences, University of Utah, ³Occupational Therapy, University of Utah, Salt Lake City, UT, United States, ⁴Neurology, University of Utah, ⁵Radiology and Imaging Sciences, Biomedical Engineering, University of Utah, Salt Lake City, UT, United States

Improved characterization of brain microstructure is important for image-based methods for diagnosing stroke. We explored the extent to which microstructural maps including Fractional Anisotropy (FA), Generalized Fractional Anisotropy (GFA), and Neurite Orientation Dispersion Density Index (NODDI) detect ipsilateral and contralateral differences in stroke patients as a measure of stroke severity. The difference between hemispheres was correlated with Fugl-Meyer Assessment motor function scores and the results of 16 patient scans reported. Results suggest that the Orientation Dispersion Index (ODI) contains information that could be clinically useful in understanding stroke recovery.

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