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Abstract #4647

31P MR Spectroscopic Imaging of the Human Brain at 7T

Jimin Ren1, Ty Shang2, A. Dean Sherry1,3, and Craig R. Malloy1,4

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Department of Chemistry, Unversity of Texas at Dallas, Richardson, TX, 4VA North Texas Health Care System, Dallas, TX, United States

31P MRS is capable of probing cerebral metabolism in vivo, but clinical applications are limited by poor spatial resolution. This study demonstrates that 31P MRS imaging (MRSI) at 7T can offer high quality spectral data that enables cross-sectional mapping of various phosphorus-bearing metabolites in normal human brain. In a patient with prior ischemic stroke, high-energy phosphates were depleted and extracellular inorganic phosphate was increased in the stroke lesion.

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