Abstract #4648

Striatal 7T 1H-MRS in two Huntington's Disease Mouse Models (zQ175 and YAC128)

Bretta Russell-Schulz¹, Andrew Yung¹, Austin Hill², Alex L MacKay^1,3, Piotr Kozlowski¹, and Blair R Leavitt²

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada, ³Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada

Two Huntington’s disease (HD) mouse models with difference rates of disease progression, zQ175 and YAC128, were examined using 7T proton magnetic resonance spectroscopy of mice aged 6-7 months. zQ175 heterozygous and homozygous genotypes showed significantly decreased [tNAA] and increased [mI] compared to wild type. No differences in metabolite concentrations were found between YAC128- (wild type) and YAC128+ mice. A slow HD disease course in YAC128+ genotype may be the reason for lack of measured metabolite concentration differences.

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