Meeting Banner
Abstract #4649

QSM meets MRS: The influence of subcortical iron on glutamatergic neurotransmission in a movement disorder population

Ahmad Seif Kanaan1,2, Alfred Anwander1, Andreas Schäfer3, Berkin Bilgic4, Torsten Schlumm1, Jamie Near5, Kirsten Müller-Vahl2, and Harald E. Möller1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Department of Psychiatry, Social Psychiatry and Psychotherpay, Hannover Medical School, Hannover, Germany, 3Diagnostic Imaging, Magnetic Resonance, Research & Development, Siemens Healthcare GmbH, Erlangen, Germany, 4Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 5Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada

We use a combination of Quantitative Susceptibility Mapping and 1H-MRS to examine the role of iron and its association with glutamatergic signalling in Gilles de la Tourette syndrome (GTS). GTS is a neurodevelopmental movement disorder with abnormalities in the neurotransmission of dopamine and GABA and, as shown more recently, also in subcortical glutamate (Glu) and glutamine (Gln). In this work, we observed that GTS patients exhibit reductions in cerebral iron levels and report a general association between iron and the Gln:Glu ratio. This work provides a good example of utilizing multi-modal neuroimaging methods to interrogate pathophyiology at multiple scales.

This abstract and the presentation materials are available to members only; a login is required.

Join Here