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Abstract #4919

Correlation of Pharmacokinetic Parameters with Prognostic factors of Breast Cancers: a Retrospective Study in Dynamic Contrast-Enhanced MRI with CAIPIRINHA-Dixon-TWIST-VIBE Technique

Yiqi Hu1, Tao Ai1, Xu Yan2, Dominik Nickel3, and Liming Xia1

1Radiology, Tongji Hospital, Wuhan, People's Republic of China, 2Siemens Healthcare, MR Collaboration NE Asia, People's Republic of China, 3Siemens Healthcare, MR Collaboration

As the use of neoadjuvant chemotherapy is gradually increased in the treatment of breast cancer, evaluating its therapeutic effect is gaining importance. This study investigated the correlation between pharmacokinetic parameters using high spatial and temporal resolution dynamic contrast-enhanced MR imaging (DCE-MRI) and the prognostic factors for breast cancers. The results showed quantitative parameters (Ktrans, kep) were significantly correlated to the prognostic factors (PR, Ki-67) of breast cancers. Quantitative parameters (Ktrans, kep) of high spatial and temporal resolution DCE-MRI may be good indicators of therapeutic effect of patients undergoing neoadjuvant treatment.

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