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Abstract #5089

Knee cartilage T2 mapping with T2-prepared isotropic 3D GRE has equivalent precision and higher accuracy compared to multi-slice TSE in volunteers and patients at 3T

Roberto Colotti1, Patrick Omoumi1, Gabriele Bonanno1,2,3, Jean-Baptiste Ledoux1, and Ruud B. van Heeswijk1

1Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, United States, 3Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, United States

The goal of this study was to compare the precision and accuracy of a novel isotropic 3D T2-prepared gradient-echo T2 mapping technique (Iso3DGRE) with the clinical standard 2D multi-slice turbo spin-echo (MS-TSE) for T2 mapping of knee cartilage at 3T. A phantom study was performed to determine the accuracy of both techniques against the reference standard spin echo (SE). T2 mapping of knee cartilage was then performed in 13 healthy volunteers and 5 patients with late-stage osteoarthritis. Compared to MS-TSE, Iso3DGRE T2 mapping resulted in T2 values with equivalent precision and slightly higher accuracy at a higher spatial resolution.

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