Abstract #5471

MR Spectroscopy shows that high fat diet changes composition and distribution of mammary gland fat in a transgenic mouse model of breast cancer

Dianning He¹, Devkumar Mustafi¹, Xiaobing Fan¹, Sully Fernandez², Erica Markiewicz¹, Marta Zamora¹, Jeffrey Mueller³, Joseph Sachleben⁴, Matthew J Brady², Suzanne D Conzen⁵, and Gregory S Karczmar¹

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Medicine, Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, IL, United States, ³Pathology, The University of Chicago, Chicago, IL, United States, ⁴Biochemistry & Molecular Biology, The University of Chicago, Chicago, IL, United States, ⁵Medicine, Hematology and Oncology, The University of Chicago, Chicago, IL, United States

Epidemiological studies show increased risk of breast cancer associated with Western diets containing high animal fat. The aim of this study was to evaluate changes in mammary fat composition due to a high animal fat diet (HAFD), compared to a low fat diet (LFD), in a mouse model of breast cancer. Localized MR spectroscopy and high spectral and spatial resolution (HiSS) MRI data were acquired at 9.4T. The saturated fat fractions increased and the polyunsaturated bond component decreased significantly in HAFD mice compared to LFD mice. Fat images obtained from HiSS demonstrated increased mammary fat concentration in HAFD mice than LED mice.

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