Collagenosis-induced narrowing of deep medullary vein (DMV) caliber has been implicated as one of the main causes of small vessel disease. However, a non-invasive imaging method for monitoring the DMV narrowing is still lacking. We present an MRI method for non-invasive measurement of DMV caliber and oxygenation level base on MRI phase and complex images acquired using a double echo gradient echo sequence at 7 T. The measured DMV caliber distribution agreed well with earlier report. Our approach can serve as an invaluable tool for studying the role of venous lumen narrowing in the pathogenesis of small vessel disease.
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