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Abstract #0477

Cardiac and respiratory motion-corrected whole-heart PET-MR imaging for simultaneous assessment of coronary anatomy, cardiac function and myocardial integrity

Camila Munoz1, Radhouene Neji2, Karl P Kunze3, Imran Rashid1, Christoph Rischpler3, Stephan G Nekolla3, René M Botnar1, and Claudia Prieto1

1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare, Frimley, United Kingdom, 3Nuclear Medicine, TU Munich, Munich, Germany

Image degradation due to cardiac and respiratory motion remains a challenge for cardiac PET-MR imaging. Here we propose a simultaneous dual-phase PET and Coronary MR angiography (CMRA) acquisition and reconstruction framework that allows for the visualisation of coronary anatomy, estimation of ventricular function and motion-corrected myocardial PET in a single efficient examination. A validation study in healthy subjects shows that left ventricular ejection fraction can be estimated from dual-phase CMRA images at 3T. Results from patients with cardiovascular disease show improvements in respiratory motion corrected dual-phase CMRA and in PET image quality when applying both cardiac and respiratory motion correction.

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