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Abstract #0587

Compartmental brain sodium concentrations in human brain tissues in white matter and grey matter: a multi-echo ultra-high field 23Na-MRI study

Ben Ridley1,2, Armin M. Nagel3,4, Mark Bydder1,2, Adil Maarouf1,2, Jan-Patrick Stellmann1,2, Soraya Gherib1,2, Jeremy Verneuil1,2, Patrick Viout1,2, Maxime Guye1,2, Jean-Philippe Ranjeva1,2, and Wafaa Zaaraoui1,2

1CRMBM, Aix-Marseille University, Marseille, France, 2CEMEREM, APHM Hôpitaux de la Timone, Marseille, France, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4German Cancer Research Centre, Division of Medical Physics in Radiology, Heidelberg, Germany

Using multi-echo 23Na-MRI at 7T acquired in 13 healthy subjects and modelling the relationship between signal and reference concentration and applying it to in vivo 23Na-MRI signal, we quantify both T2* decay times and concentrations associated with short and long components for the first time. Relaxation times and concentrations differed between grey and white matter and subregions of differing tissues, suggesting sensitivity of 23Na toward features of tissue composition. As such, these results raise the prospect of multi-echo 23Na-MRI as an adjunct source of information on biochemical mechanisms in both physiological and pathophysiological states.

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