Abstract #0634

Mapping of Glioma Metabolism Using In Vivo Deuterium Metabolic Imaging (DMI)

Henk M. De Feyter¹, Kevin L. Behar², Peter B. Brown¹, Douglas L. Rothman^1,3, and Robin A. de Graaf^1,3

¹Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Department of Psychiatry, Yale University, New Haven, CT, United States, ³Department of Biomedical Engineering, Yale University, New Haven, CT, United States

Deuterium Metabolic Imaging (DMI) is a novel approach providing high 3D spatial resolution metabolic data from both animal models and human subjects. DMI relies on ²H MRSI in combination with administration of ²H-labeled substrates. In a rat glioma model we show how DMI combined with administration of [6,6’-²H₂]-glucose and [²H₃]-acetate allowed spatial mapping of differences in metabolism between normal brain and glioma. DMI data after infusion of ²H-labeled glucose revealed high glucose uptake and lactate production but limited glucose oxidation in glioma. Furthermore, DMI revealed acute therapeutic effects of a drug (dichloroacetate) targeting glucose oxidation.

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