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Abstract #0635

COX-2 Alters the Metabolic Secretome in Triple Negative Human Breast Cancer Xenografts

Santosh Kumar Bharti1, Paul T Winnard Jr.1, Yelena Mironchik1, Louis Dore-Savard2, Balaji Kirshnamachary1, and Zaver M Bhujwalla1,3

1Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2McGill University Health Centre and RI-MUHC, Montreal, QC, Canada, 3Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

Tumor interstitial fluid (TIF) contains the tumor secretome and forms a critical component of the tumor microenvironment. Cyclooxygenase-2 (COX2) mediates the inflammatory response of cells and is upregulated in cancers. In cancers, COX-2 expression has been related to increased invasion and metastasis. Here, for the first time, using 1H MR spectroscopy we characterized changes in the metabolic patterns of TIF in tumors derived from triple negative SUM-149 human breast cancer cells with COX-2 overexpressed. COX-2 overexpression significantly altered several fundamental metabolic pathways. These data provide new insights into the role of COX-2 in tumor aggressiveness, and identify new metabolic targets.

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